Sunday, May 31 — Rex Daily

I Daily Wisdom

Robert Greene The Daily Laws May 31 · Know Who You’re Dealing With

Be convinced, that there are no persons so insignificant and inconsiderable, but may, some time or other, have it in their power to be of use to you; which they certainly will not, if you have once shown them contempt.

—Lord Chesterfield

The ability to measure people is the most important skill of all in gathering and conserving power. Without it you are blind: not only will you offend the wrong people, you will choose the wrong types to work on and will think you are flattering people when you are actually insulting them. Before embarking on any move, take the measure of your mark or potential opponent. Otherwise you will waste time and make mistakes. Study people’s weaknesses, the chinks in their armor, their areas of both pride and insecurity. Know their ins and outs before you even decide whether or not to deal with them. Two final words of caution: First, in judging and measuring your opponent, never rely on your instincts. You will make the greatest mistakes of all if you rely on such inexact indicators. Nothing can substitute for gathering concrete knowledge. Study and spy on your opponent for however long it takes; this will pay off in the long run. Second, never trust appearances. Anyone with a serpent’s heart can use a show of kindness to cloak it; a person who is blustery on the outside is often really a coward. Never trust the version that people give of themselves—it is utterly unreliable.

Daily Law: What possible good can come from ignorance about other people? Learn to tell the lions from the lambs or pay the price.

The 48 Laws of Power

, Law 19: Know Who You’re Dealing With—Do Not Offend the Wrong Person

Steven Pressfield The Daily Pressfield Day 151

THINK ING BIG When we’re starting out in any field, timidity can get the best of us. “I can’t write a novel. Let me try a short story.” “Let me try a blog…or an Instagram post.” “Lemme try a tweet.” Unpublished Black Irish JAB, “Think in Cam paigns” When I started out as a junior copywriter at Benton & Bowles in New York, I used to bring in the teensiest, tiniest, most timorous ideas to my boss, Ed Hannibal. His head would explode with frust ration. “What is this you’re bringing me, Steve? This idea is the size of a postage stamp! Get outa here and come back with somethin g big !” Ed’s primary mantra: “Don’t think in ads. Think in camp aigns.”

Leo Tolstoy A Calendar of Wisdom May 31

A person who is not used to luxury, but who acquired luxury quite by chance, often pretends, in order to become more important in his own eyes and in the eyes of other people, that luxury is natural for him, that he is not surprised by it, that he neglects it.

In the same way a stupid person pretends that he is bored with life, and that he can find something more interesting.

The joy of your spirit is the indication of your strength.

—RALPH WALDO EMERSON

You must believe in the possibility of happiness in order to be happy.

Take from a person who follows the divine law everything which other people think of as comfort and wealth, and nevertheless such a person will remain happy.

A person who has spoiled his stomach will criticize his meals saying that the food is bad; the same thing happens with people who are not satisfied with their lives in this world.

We do not have the right to be unhappy with our life.

If it seems to us that we are not satisfied with life, we should see this as a reason to be unsatisfied with ourselves.

III Signals & Dispatches

AI / ML

@systematicls source ↗ System harness features like memory and tooling are being absorbed into frontier models, so the moat is shifting toward execution and workflow design.
@emollick source ↗ Benchmarks keep flattering open weight models, but out of distribution fragility still looks worse than leaderboard culture admits.

Drug Discovery

@DealroomAgent source ↗ Isomorphic Labs just raised a $2.1B Series B to scale its AI drug design engine and push multiple therapeutic programs forward.
@vikasmalpani source ↗ An AI designed drug reportedly reached a successful Phase 2 in lung disease at a fraction of the usual discovery cost and timeline.

Biotech

@InstituteCicero source ↗ US biotech policy is being framed as a competitiveness fight with China, with FDA simplification and AI acceleration at the center.
@ScienceCrisp source ↗ A new paper on endogenous CRISPR engineering in probiotic Lacticaseibacillus points to cleaner strain editing inside production microbes.

Tech

@LeakerApple source ↗ Rumors say Nvidia's ARM based workstation chip could ship with up to 128GB unified memory, which would make it a serious local AI development machine.
@kenta_akagi source ↗ Hugging Face's new Enterprise Hub pitch is speed: tighter MLOps plus Dell tuned infrastructure for faster production rollout.

Japanese Politics

@koichi_kawakami source ↗ Critics are still hammering the LDP over unresolved Unification Church ties and the return of Abe faction slush fund figures.
@risc2004 source ↗ A conservative voter gripe gaining traction is that the LDP talks tradition but will not seriously reverse immigration growth.

IV Sky over Ibaraki

☀️ +20°C

humidity 60% · wind ↓4km/h

clear and calm morning

V What Rex Can Do Today

Pull 3 fresh AI drug discovery papers and turn them into a one page brief with what actually matters for peptide work.
Draft one recruiter or founder outreach note built around Boss's TRIM3, TRIM4, and TRIM5 story without exposing confidential details.
Tidy the current CV folder, check for stale variants, and sync the strongest set to Dropbox.

VI Toward the Long Game

Read one serious paper on generative molecular or peptide design and write 5 hard takeaways, not a fluffy summary.
Build a tiny notebook that compares two open molecular models on one concrete design task so Boss has something demoable.
Send one thoughtful note to a biotech AI person in Japan, Singapore, or global pharma with a specific question or angle.