Tuesday, June 9 — Rex Daily

I Daily Wisdom

Robert Greene The Daily Laws June 9 · Give People the Opportunity to Feel Superior

Some people will see an appeal to their self-interest as ugly and ignoble. They actually prefer to be able to exercise charity, mercy, and justice, which are their ways of feeling superior to you: when you beg them for help, you emphasize their power and position. They are strong enough to need nothing from you except the chance to feel superior. This is the wine that intoxicates them. They are dying to fund your project, to introduce you to powerful people—provided, of course, that all this is done in public, and for a good cause (usually the more public, the better). Not everyone, then, can be approached through cynical self-interest. Some people will be put off by it, because they don’t want to seem to be motivated by such things. They need opportunities to display their good heart. Do not be shy. Give them that opportunity. It’s not as if you are conning them by asking for help—it is really their pleasure to give, and to be seen giving.

Daily Law: You must figure out what makes others tick. When they ooze greed, appeal to their greed. When they want to look charitable and noble, appeal to their charity.

The 48 Laws of Power

, Law 13: When Asking for Help, Appeal to People’s Self-Interest, Never to Their Mercy or Gratitude

Steven Pressfield The Daily Pressfield Day 160

THE AMATEUR LIVES BY THE OPINIONS OF OTHERS The amateur allows his worth and identity to be defined by others. The amateur craves third-party validation. The amateur is tyrannized by his imagined conception of what is expected of him. He is imprisoned by what he believes he ought to think, how he ought to look, what he ought to do, and who he ought to be. Turning Pro, p. 56 When we turn pro, we accept responsibility for who we are. We step out of the shadow of ought-to-be and should-be and how-we-are-expected -to-be.

Leo Tolstoy A Calendar of Wisdom June 9

Christian society, as it now exists, doesn’t follow Christian law in its real meaning.

Almost every effort of the human mind is directed, not toward lightening the work of the laborer, but toward making more pleasant the idleness of the leisured.

If a person could look at our world from a distance he would see so much stupidity and hatred that he would probably cry.

We do so many funny and stupid and impoverished hateful deeds.

One person hunts wild animals and becomes an animal himself; another feeds donkeys and horses to carry loads, and despises people who die of hunger.

Other people spend a great deal of money to create huge houses and do nothing to help the homeless.

Some people seek only profits, others spend only for dissipation, and others steal.

In all of these excesses, all of this criminal behavior, we see people who only want to take care of themselves, without a thought about what is most necessary in this world.

—SAINT JOHN CHRYSOSTOM

It defies the laws of nature for a child to rule an adult, or a fool to guide a wise man.

Likewise, it is against the law of nature that a small group of people should be overindulged when a huge, hungry crowd’s most basic needs aren’t met.

There is only one thing in this world which is worth dedicating all your life.

This is creating more love among people and destroying barriers which exist between them.

II The Day Ahead

Tomorrow · 15:00 基礎研全体Mtg (Group B) 基礎研全体Mtg 2026

III Signals & Dispatches

AI / ML

@shannholmberg source ↗ Agent looping is becoming the real upgrade over one shot prompting, with agents now expected to research, draft, check, and iterate until the work clears the bar.
@0x_rody source ↗ An Anthropic workflow note says reusable commands should live inside the project, which is a concrete sign that serious teams are turning prompts into operating muscle.

Drug Discovery

@tech_vayu source ↗ Isomorphic Labs entering human trials with an AI designed cancer drug is the clearest reminder that this field is finally pushing past demos and toward clinical proof.
@doroeee source ↗ Samsung Medical Center and Samsung Bioepis are building a shared AI target discovery engine through 2030, which shows large Asian groups are fusing clinic and wet lab data more tightly.

Biotech

@moe4588oncolys source ↗ Oncolys says Telomelysin injection just won standard manufacturing and marketing approval, a concrete late stage regulatory win in Japanese biotech.
@IntegralAnswers source ↗ Verve's VRV102 base editing story is gaining attention because the pitch is a one time infusion that permanently silences PCSK9 and lowers LDL for years.

Tech

@OpenAINewsroom source ↗ OpenAI says it has confidentially filed an S 1, keeping an IPO on the table while admitting some of its core work may still be easier to do in private.
@signulll source ↗ One sharp WWDC takeaway is that Apple may be inching from an app centric world toward an intent centric one, where AI assembles the interface you need on demand.

Japanese Politics

@jimin_koho source ↗ The LDP line is that the supplementary budget is through and execution now shifts to Middle East risk, ASEAN diplomacy, and the final month of the Diet session.
@shintayabe_257 source ↗ The loudest political drag on Takaichi is still the smear video affair, especially because each defense about what counts as an acquaintance now looks like moving the goalposts.

IV Sky over Ibaraki

🌤️ +18°C

humidity 94% · wind →5 km/h

humid, light easterly breeze

V What Rex Can Do Today

Draft a one page note on what the Isomorphic, Samsung, and Verve signals imply for StemRIM's peptide moat and data strategy.
Prepare a tight pre read for tomorrow's 基礎研全体Mtg, with likely discussion points and one worthwhile question Boss could raise.
Sweep for any messages or documents tied to tomorrow's meeting and prewrite short replies if something needs action before lunch.

VI Toward the Long Game

Sketch one closed loop agent workflow for a real StemRIM task today, such as paper triage, competitor scanning, or meeting brief generation.
Read the Isomorphic clinical trial signal with one question in mind: what evidence would prove AI is helping the biology rather than just accelerating the paperwork.
Spend half an hour on base editing, especially the VRV102 story, to sharpen your feel for where permanent genetic interventions differ from peptide therapeutics.