Sunday, June 14 — Rex Daily

I Daily Wisdom

Robert Greene The Daily Laws June 14 · Deter with a Threatening Presence

When opponents are unwilling to fight with you, it is because they think it is contrary to their interests, or because you have misled them into thinking so.

—Sun Tzu

We all have to fit in, play politics, seem nice and accommodating. Most often this works fine, but in moments of danger and difficulty being seen as so nice will work against you: it says that you can be pushed around, discouraged, and obstructed. If you have never been willing to fight back before, no threatening gesture you make will be credible. Understand: there is great value in letting people know that when necessary you can let go of your niceness and be downright difficult and nasty. A few clear, violent demonstrations will suffice. Once people see you as a fighter, they will approach you with a little fear in their hearts. And as Machiavelli said, it is more useful to be feared than to be loved. Uncertainty is sometimes better than overt threat: if your opponents are never sure what messing with you will cost, they will not want to find out.

Daily Law: Build up a reputation: You’re a little crazy. Fighting you is not worth it. Create this reputation and make it credible with a few impressive—impressively violent—acts.

The 33 Strategies of War

, Strategy 10: Create a Threatening Presence—Deterrence Strategies

Steven Pressfield The Daily Pressfield Day 165 · NO MORE MISTER NICE GUY I

ust came back from vacation and I’m about to plunge in on a Big New Project. My first note to myself is, “START SAYING NO.” I hereby vow to stop saying yes to things. First I’ll stop saying yes to things I want to do. My friend Jake, who has tickets to Springsteen? Pass. I’ll go to Lou and Rachel’s wedding. I’ll be there for the festivities after. But I can’t stay out all night, and I won’t do anything that’ll leave me in no shape to work the next morning. People are gonna get pissed at me. I’m sorry. I’m like the Blues Br others. I’m on am ission. Black Irish JAB #5, “Learning to Say No” Why do I say no? Because I know what it feels like at the end of the day when I’ve said yes to some bogus “opportunity” because I thought I ought to, or I didn’t want to offend someone, or because it seemed like what a Nice Guy would do.

Leo Tolstoy A Calendar of Wisdom June 14

When you make an effort not to blame other people, your life becomes much easier, but very few people make this small effort.

In the lives of the saints, there is the story of the hermit who saw in his dream a monk who had died long ago, and who had been rather weak in his life.

The monk was in an especially lovely and honored part of paradise.

The hermit asked, “How were you granted this place, with all your weaknesses?” and the monk answered that it was because he had never blamed, not a single person in his life.

Therefore thou art inexcusable, O man, whosoever thou art that judgest: for wherein thou judgest another, thou condemnest thyself; for thou that judgest doest the same things.

—ROMANS 2:1

The more strictly and mercilessly you judge yourself, the more just and kind you will be in the judgment of others.

—CONFUCIUS

Do not glorify in blaming and despising other people.

A kind person should hide the shame of others, even those who have harmed him.

Do not remember one who repents his former sins.

—The TALMUD

Unless you yourself are sinless, do not say a single word about the sins of others, but be quiet.

If you make it a habit not to blame others, you will feel the growth of the ability to love in your soul, and you will see the growth of goodness in your life.

II The Day Ahead

Tomorrow · 14:00 個別Mtg 個別Mtg 2026

III Signals & Dispatches

AI / ML

@ClaudeDevs source ↗ Claude Fable 5 was suspended across products after a US directive, a reminder that frontier model access can vanish overnight.
@emollick source ↗ Ethan Mollick argues bigger models often beat smaller ones even on routine work, so the real tradeoff is cost rather than task importance.

Drug Discovery

@kimmonismus source ↗ Anthropic says Mythos 5 helped internal protein design experts accelerate parts of drug design by about 10x, sometimes matching skilled human operators.
@FarhanBuildsAI source ↗ Isomorphic Labs is reportedly nearing first human trials for AI designed drugs, pushing the field from demo to clinic.

Biotech

@EricTopol source ↗ Phase 3 data for one shot CRISPR editing in hereditary angioedema looked strong enough to make in vivo gene editing feel clinically real.
@NikoMcCarty source ↗ A WuXi field note argues China’s biotech edge now rests on scaled services, automation, and FDA inspected manufacturing rather than cheap labor alone.

Tech

@orfonline source ↗ Semiconductors are being treated as strategic assets, with chip supply now tied directly to AI, defense, and economic security.
@Chaamacoo source ↗ One semiconductor bull case says the AI stack is shifting from copper to optical links, creating leverage for suppliers built around high speed interconnects.

Japanese Politics

@tomozo067 source ↗ A fresh Japanese political gripe is that imperial house law reform is being pushed as a Diet priority while voters want bread and butter issues handled first.
@nagata4273 source ↗ Another thread of chatter says opposition attacks on PM Takaichi over weekly magazine evidence are devolving into process warfare rather than substance.

IV Sky over Ibaraki

🌤️ +23°C

humidity 69% · wind ↙7km/h

bright morning with a light breeze

V What Rex Can Do Today

Pull three fresh AI drug discovery papers and give Boss a one page signal memo tied to peptide design and translational risk.
Draft a short internal note on what the Fable shutdown means for local model strategy, tooling resilience, and data control in pharma teams.
Preflight today’s Fr. Conor pipeline inputs so any file or message cleanup is done before the next content handoff.

VI Toward the Long Game

Read one serious paper on AI accelerated molecular dynamics or protein design and write five implications for TRIM style peptide work.
Build a tiny benchmark of open models on real peptide and bioinformatics prompts so local capability becomes concrete, not theoretical.
Send one crisp networking note to an AI drug discovery operator or recruiter in Japan or Singapore with your bioinformatics and peptide discovery angle.