Tuesday, June 23 — Rex Daily

I Daily Wisdom

Robert Greene The Daily Laws June 23 · Play to Their High Self-Opinion

The true spirit of conversation consists more in bringing out the cleverness of others than in showing a great deal of it yourself.

—Jean de La Bruyère

If you need a favor from people, do not remind them of what you have done for them in the past, trying to stimulate feelings of gratitude. Gratitude is rare because it tends to remind us of our helplessness, our dependence on others. We like to feel independent. Instead, remind them of the good things they have done for you in the past. This will help confirm their self-opinion: “Yes, I am generous.” And once reminded, they will want to continue to live up to this image and do yet another good deed. A similar effect can come from suddenly forgiving your enemies and forging a rapprochement. In the emotional turmoil this creates, they will feel obligated to live up to the high opinion you have now shown toward them and will be extra motivated to prove themselves worthy.

Daily Law: Stimulate feelings of a high self-opinion in your targets.

The Laws of Human Nature

, 7: Soften People’s Resistance by Confirming Their Self-Opinion—The Law of Defensiveness

Steven Pressfield The Daily Pressfield Day 174

HORSE AN D RIDER “A cavalryman’s horse should be smarter than he is. But the horse must never be allowed to know this.” The Virtues of War, p. 183 [hardback] I actually stole this quote from a book (probably The Memoirs of Baron de Marbot, one of my all-time faves) I was using to research cavalry tactics for The Virtues of War. I’m not sure what the quip even means. The closest I can come is this: We as artists enter battle propelled by our Muse. Yes, she is stronger. Indeed, she is wiser. She is the thunderbolt. We are hanging on for dear life. But despite it all, you and I must grip the reins with conviction and keep our seat no matter how furiously the creature beneath us gallops or how recklessly she propels us into the melee.

Leo Tolstoy A Calendar of Wisdom June 23

Only he who accepts that the essence or meaning of his life is not material but spiritual can be free.

A slave who is happy with his state is a slave twice over, because not only his body but his soul is enslaved.

O God, while I stay on this earth I want to be that which I am.

—EPICTETUS

Peace is a great blessing if it can be reached, but if peace is reached by slavery, it becomes a misfortune and not a blessing.

Peace is the freedom which is based on the acceptance of every person’s rights, and slavery is the negation of rights, and of human dignity.

Therefore, we should sacrifice everything to achieve peace, but even more, to get rid of slavery.

—After MARCUS TULLIUS CICERO

Remember that you are more free if you change your opinion and follow those who have corrected your mistakes, than if you are stubborn about your mistakes.

—MARCUS AURELIUS

There is only one real knowledge: that which helps us to be free.

Every other type of knowledge is mere amusement.

—VISHNU PURANA, INDIAN WISDOM

There is no middle way: either be a slave of people or of God.

II The Day Ahead

Tomorrow · 15:00 ⭐ 基礎研全体Mtg (Group A) - Presentation 基礎研全体Mtg 2026

III Signals & Dispatches

AI / ML

@theo source ↗ Theo suggests a simple agentic code loop: have Codex finish an API design, then ask Opus for a second opinion before shipping.
@Raytar source ↗ A Meta conference anecdote says Boris Cherny now codes mostly through Claude, a useful signal that senior builders are normalizing IDE light workflows.

Drug Discovery

@NatRevDrugDisc source ↗ Nature Reviews Drug Discovery points to BIO2026 discussion on how quiet AI gains at Amgen could reshape drug research and development.
@CaptialDigest source ↗ A reported 2.5 billion dollar SK Biopharmaceuticals partnership highlights neuroimmune therapy as a serious target for AI driven discovery.

Biotech

@BioSignal source ↗ Qihan Biotech reportedly won Fast Track, RMAT, and Breakthrough tags for an allogeneic CD19 cell therapy, a sharp China biotech signal.
@FreightWaves source ↗ UPS opened 27 temperature controlled cross dock sites, another sign that pharma and biotech cold chain demand keeps expanding.

Tech

@tailopez source ↗ A reminder from the startup world: the average successful founder is closer to 45 than 22, which favors accumulated judgment over youthful theater.
@MoJalloh source ↗ Misinformation remains a top global risk, and the sharper point is cultural: better tools have not automatically produced better truth seeking.

Japanese Politics

@fm21wannuumui source ↗ A post urges Diet members and MEXT to investigate alleged violations of political neutrality rules in schools.
@mTrARQ9C6v3enbu source ↗ A sharp Diet criticism frames written statements and refused questioning as a way for politicians to run out the clock.

IV Sky over Ibaraki

🌤️ +22°C

humidity 73% · wind ↘7km/h

mild and breezy in Ibaraki

V What Rex Can Do Today

Turn today’s AI and drug discovery signals into a short reading queue for Boss, with one paper and one implementation idea.
Check the job and CV folders for any stale draft material that can be tightened into application ready language.
Review recent memory notes and promote durable career or StemRIM context into long term memory if anything matters.

VI Toward the Long Game

Read one recent AI drug discovery paper with a focus on representation learning for molecules or peptides, then write a five bullet implementation note.
Spend 30 minutes building a tiny RDKit or protein embedding notebook that can become a portfolio artifact.
Message one AI drug discovery contact or recruiter with a concrete update, not a generic “checking in”.