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REX·DAILY
Friday June 26 Anno 2026 · Ibaraki, Osaka
I Daily Wisdom
Robert Greene The Daily Laws June 26 · Never Conventional

No one is so brave that he is not disturbed by something unexpected.

—Julius Caesar

The unconventional is generally the province of the young, who are not comfortable with conventions and take great pleasure in flouting them. The danger is that as we age, we need more comfort and predictability and lose our taste for the unorthodox. This is how Napoleon declined as a strategist: he came to rely more on the size of his army and on its superiority in weapons than on novel strategies and fluid maneuvers. He lost his taste for the spirit of strategy and succumbed to the growing weight of his accumulating years. You must fight the psychological aging process even more than the physical one, for a mind full of stratagems, tricks, and fluid maneuvers will keep you young. Keep the wheels turning and churning the soil so that nothing settles and clumps into the conventional.

Daily Law: Make a point of breaking the habits you have developed, of acting in a way that is contrary to how you have operated in the past; practice a kind of unconventional warfare on your own mind.

The 33 Strategies of War

, Strategy 24: Take the Line of Least Expectation—The Ordinary-Extraordinary Strategy

Steven Pressfield The Daily Pressfield Day 177

THE STAKES INCREASE IN ACT TWO Marriage Story starts with Nicole and Charlie Barber (Scarlett Johansson and Adam Driver) simply wanting to separate on civil terms. But by the end of Act Two, Charlie is shouting, “I wish you were dead!” and hiding his face in shame at the words that have just erupted from his mouth. Each step in this story (consulting an attorney, consulting a second attorney, going before a judge) escalates the stakes for both characters as grimly and as inevitably as the Act Two stages of a murder mystery or a doomsday thriller This is exactly as it should be. Writing Seminar, Nashville, 2019 When my own second act starts beating the crap out of me, I sometimes get out the index cards and write one for each scene. I pin them to the wall in sequence and ask myself, “Is each scene escalating the stakes of the story?” If scene after scene remains at the same level of jeopardy and the same level of consequence, I know I haven’t ratcheted up the tension or made the price of failure for my hero(es) higher and more terrifying with each passing beat.

Leo Tolstoy A Calendar of Wisdom June 26

Love provides a person with the purpose of his life.

Intellect shows him the means to achieve that purpose.

In the scheme of the world, a person is no more than a pine cone, or a weak herb, or a bit of swamp grass, but he is a grass which possesses some intellect.

—BLAISE PASCAL

Man differs from other animals only in his intellect; some people try to develop it and others neglect it, just as they try to reject those other qualities which differentiate them from the animals.

—EASTERN WISDOM

I praise Christianity because it develops, strengthens, and elevates my intellectual nature.

—WILLIAM ELLLERY CHANNING

If a person lacks intellect, he can not distinguish bad from good, and so he can neither truly seek nor truly have real goodness.

II The Day Ahead
  • Tomorrow · 09:00 毎月の黙想会 2026年間予定
III Signals & Dispatches

AI / ML

  • @saera_aisource ↗ AlphaFold系の研究者が論文機関ではなくAIスタートアップへ流れる構造を、基礎科学と実装の境界変化として読んでいる。
  • @shiho_agasource ↗ OpenAIのIPO先送り観測を、成長期待、計算資源コスト、規制対応を市場に説明するタイミング問題として整理している。
  • @vbkotechasource ↗ Realbotixの人型ロボットがSeneca Nationの学校でSTEM補助に入る実例を、教師代替ではなく教師拡張として位置づけている。

Drug Discovery

  • @younghope11source ↗ Nature Reviews Drug DiscoveryのAI標的発見レビューを、候補列挙より実験と臨床で検証する階段設計が本質だと要約している。
  • @_BrightFocussource ↗ UCLAとUSCのアルツハイマー病パイロットで、AI薬物設計と疾患モデルを組み合わせ毒性タウ阻害を探索する。
  • @agihouse_orgsource ↗ Eli Lillyが社内の創薬AIモデルを小規模バイオテックへ無償提供する構想を紹介している。

Biotech

  • @GPECsource ↗ BIO 2026でGreater Phoenixがバイオテック集積地としての成長材料を売り込んでいる。
  • @b2idigitalsource ↗ eXoZymesがAI設計酵素による希少カンナビノイド創薬プログラムでNIHから約200万ドルの助成を得た。
  • @AppleHelixsource ↗ 市場資金がAIサプライチェーンへ偏る一方、バイオテック株の値動きは比較的合理的だったという観察。

Tech

  • @HarryStebbingssource ↗ AI企業の初期100人組織は、少人数で高密度に働くエリート型へ変わったという議論を投げている。
  • @MKBHDsource ↗ メモリ価格上昇がApple製品価格に波及し始めたという指摘が広く拡散している。
  • @businesssource ↗ 米陸軍基地を重要鉱物処理施設に使う構想は、再工業化と安全保障がテック供給網に直結していることを示す。

Japanese Politics

  • @MisterHR_japansource ↗ 自民党と国民民主党の幹部会談で、終盤国会、皇室典範改正、食料品の消費税減税が話題に上った。
  • @shio02493746source ↗ 皇室典範改正案について、女性皇族の婚姻後皇籍維持と男系男子継承の明文化を求める保守側の論点が出ている。
  • @shigotoninsource ↗ 自民党政調全体会議で経済財政運営と改革の基本方針2026骨子が議論される。
IV Sky over Ibaraki
🌧️ +23°C
humidity 94% · wind ↗15km/h
rainy and humid morning, carry an umbrella
V What Rex Can Do Today
  1. Check unread Gmail for anything urgent and filter out Substack noise.
  2. Review the Fr. Conor pipeline after yesterday’s title drift fix and confirm today’s scheduled release metadata.
  3. Draft a concise AI drug discovery LinkedIn note from today’s NRDD target discovery review.
VI Toward the Long Game
  1. Read the Nature Reviews Drug Discovery AI target discovery review and extract 5 validation checkpoints useful for StemRIM peptide work.
  2. Spend 30 minutes implementing a tiny molecular property prediction notebook with RDKit plus a modern tabular baseline.
  3. Message one AI drug discovery contact or recruiter with a specific angle: peptide design, MSC mobilization, or translational validation.