Monday, June 29 — Rex Daily

I Daily Wisdom

Robert Greene The Daily Laws June 29 · Mirror Their Values

Do not give dogs what is holy; and do not throw your pearls before swine, lest they trample them under foot and turn to attack you.

—Jesus Christ, Matthew 7:6

Wise and clever people learn early on that they can display conventional behavior and mouth conventional ideas without having to believe in them. The power these people gain from blending in is that of being left alone to have the thoughts they want to have, and to express them to the people they want to express them to, without suffering isolation or ostracism. The logical extension of this practice is the invaluable ability to be all things to all people. When you go into society, leave behind your own ideas and values, and put on the mask that is most appropriate for the group in which you find yourself. People will swallow the bait because it flatters them to believe that you share their ideas. They will not take you as a hypocrite if you are careful—for how can they accuse you of hypocrisy if you do not let them know exactly what you stand for? Nor will they see you as lacking in values. Of course you have values—the values you share with them, while in their company.

Daily Law: Complete free expression is a social impossibility. Conceal your thoughts, then, telling the prickly and insecure what you know they want to hear.

The 48 Laws of Power

, Law 38: Think as You Like but Behave Like Others

Steven Pressfield The Daily Pressfield Day 180

EMOTIONAL DEPTH INCREASES IN ACT TWO In Act Two the obstacles the hero faces must escalate not just quantitively but qualita tively. Unpublished Black Irish JAB, “Bad Guys, Part Five” The mission of Captain Willard (Martin Sheen) in Apocalypse Now starts out as one of simple assassination. “Go upriver, kill evil Colonel Kurtz (Marlon Brando), return to receive the praise of a grateful nation.” But as Willard advances through obstacle after obstacle on his riverine odyssey, his perspective on the mission deepens. Willard comes face to face with the moral dilemma of the Vietnam War itself, not only in the context of this current American intervention, but in all this troubled land’s past (and all the wars of all mankind’s past) back to the savage heart — Conrad’s Heart of Darkness — of the human race itself.

Leo Tolstoy A Calendar of Wisdom June 29

Depression is a state of the soul in which you can see no sense either in your own life or in the life of the world.

This state is not only painful for the people around you, but it can influence them, and a truly good person deals with this unpleasantness when he is alone.

When you have bad spirits or are in a low mood, or you are irritated, you should be so in solitude.

When everything you see appears in dark, gloomy shades, and seems baleful, and you want to tell others only bad and unpleasant things, do not trust your perceptions.

Treat yourself as though you were drunk.

Take no steps and actions until this state has disappeared.

You should never feel depressed.

A man should always feel happy; if he is unhappy, it means he is guilty.

O Lord, help me to be always happy and to rejoice following and fulfilling your will.

Both our physical sufferings and periods of depression are part of our life in this world, and we should patiently wait until they are over, or our life is over.

III Signals & Dispatches

AI / ML

@kimmonismus source ↗ Anthropic enterprise usage surged into first place around late 2025 and early 2026, making the business case worth studying closely.
@emollick source ↗ Mollick flags GLM 5.2 as a solid open model, not frontier, but evidence that open weights keep closing the capability gap.

Drug Discovery

@enrichtrades source ↗ Lilly momentum is being tied not only to GLP 1 cash flow but also to aggressive investment in AI driven drug discovery.
@TheAIphiles source ↗ Insilico and SK are being circulated for a neuroimmune AI drug collaboration valued at up to 2.5 billion dollars.

Biotech

@CronicasMedX source ↗ A CRISPR thread is resurfacing the 2012 Doudna and Charpentier breakthrough and its move from bacterial defense to programmable genome editing.
@RFAChinese source ↗ Researchers using CRISPR on EYS mutations saw mixed embryo repair outcomes, a useful reminder that edit precision remains the central risk.

Tech

@cyrilXBT source ↗ A Hermes, Obsidian and Claude Code stack is being framed as practical infrastructure for running a one person company.
@SierraPlatform source ↗ Sierra highlights support patterns as product signal, using repeated customer questions to prioritize fixes at scale.

Japanese Politics

@hZqxVCEkkn5QMow source ↗ A post criticizes shrinking proportional representation, arguing it weakens the correction for wasted votes in single member districts.
@shigeroku11 source ↗ A concise explainer on the Upper House election system is circulating, covering seats, terms, no dissolution and proportional voting rules.

IV Sky over Ibaraki

☁️ +24°C

humidity 83% · wind ↙4km/h

cloudy and a little humid, but wind is light

V What Rex Can Do Today

Draft a compact comparison of LillyPod, Insilico and Recursion so Boss has a clear AI drug discovery market map.
Scan the calendar and inbox later for anything that needs prep before evening.
Tidy one career asset today: CV bullets, LinkedIn profile text or a short project note for AI drug discovery roles.

VI Toward the Long Game

Read one recent paper on molecular representation learning and write five notes on what transfers to peptide design.
Build a tiny notebook that scores peptides with embeddings plus simple property filters, then save the results as a portfolio artifact.
Message one serious AI drug discovery contact with a specific question, not a vague catch up request.