archive
REX·DAILY
Sunday August 23 Anno 2026 · Ibaraki, Osaka
I Daily Wisdom
Robert Greene The Daily Laws August 23 · Find Their Thumbscrew

Find out each man’s thumbscrew. ’Tis the art of setting their wills in action. It needs more skill than resolution. You must know where to get at anyone. Every volition has a special motive which varies according to taste. All men are idolaters, some of fame, others of self-interest, most of pleasure. Skill consists in knowing these idols in order to bring them into play. Knowing any man’s mainspring of motive you have as it were the key to his will.

—Baltasar Gracián

We all have resistances. We live with a perpetual armor around ourselves to defend against change and the intrusive actions of friends and rivals. We would like nothing more than to be left to do things our own way. Constantly butting up against these resistances will cost you a lot of energy. One of the most important things to realize about people, though, is that they all have a weakness, some part of their psychological armor that will not resist, that will bend to your will if you find it and push on it. Some people wear their weaknesses openly, others disguise them. Those who disguise them are often the ones most effectively undone through that one chink in their armor.

Daily Law: Everyone has a thumbscrew, a gap in the castle wall. Once found, it is a thumbscrew you can turn to your advantage.

The 48 Laws of Power

, Law 33: Discover Each Man’s Thumbscrew

Steven Pressfield The Daily Pressfield Day 235

IN THE ALL IS LOST MOMENT, THE HERO HITS THE WALL In Chinatown, Jake Gittes’ (Jack Nicholson) All Is Lost Moment comes when Evelyn Mulwray (Faye Dunaway) blurts out, as Jake slaps her across the face, “She’s my sister! She’s my daughter!” At that moment, Jake realizes the scale of the evil he is up against and has been up against, without realizing it, throughout the story. Like Rocky, Jake understands now that he is way out of his league. Unpublished Black Irish JAB, “The All Is Lost Moment” In both Rocky and Chinatown, the hero thought he understood his situation. He imagined he grasped the scale of the forces arrayed again st him. In the All Is Lost Moment, the hero realizes he has misapprehended everything. He is not the person he thought he was, and he is not up against the enemy he believed he was. Our hero realizes he is outmanned, outnumbered, out gunned. In his mind he concludes he has no chance to prevail.

Leo Tolstoy A Calendar of Wisdom August 23

If people were completely virtuous, they would never step aside from the truth.

And this is the condemnation, that light is come into the world, and men loved darkness rather than light, because their deeds were evil.

For every one that doeth evil hateth the light, neither cometh to the light, lest his deeds should be reproved.

But he that doeth truth cometh to the light, that his deeds may be made manifest, that they are wrought in God.

—JOHN 3:19-21

Don’t be afraid of a person in any position, in low or high standing, whether he is a scholar or an ignorant person.

If you respect all people, you should love all people, and fear no one.

—WILLIAM ELLERY CHANNING

The consequences of any good thing which you have done in your life will die as soon as you step aside from the truth.

The high spirit which lives in you and which is united with you is looking all the time for good and evil.

—MANU

Truth can be understood only by waiting and watching, and when you get one truth, two more will appear before you.

—JOHN RUSKIN

The truth is harmful only to evildoers.

Those who do good love the truth.

II The Day Ahead
  • Today · all day Jakarta trip with Minori and Eisuke ewijaya@gmail.com
  • Today · 14:15 Fr. Conor YouTube handoff, retry security and Manager access ewijaya@gmail.com
III Signals & Dispatches

AI / ML

  • @0x0SojalSecsource ↗ A local Qwen3.8 27B release is being promoted as a multimodal model that runs on 16 GB hardware.
  • @kimmonismussource ↗ Users are reporting that Fable's high reasoning setting may have silently mapped to a much lower effort level after a recent update.

Drug Discovery

  • @Dalmatian97422source ↗ Insilico's Rentosertib is being watched as a major test of whether an AI discovered target and molecule can reach approval in Phase III.
  • @NomosLogicsource ↗ A new perspective argues that AI drug discovery needs two complementary engines rather than a single model driven workflow.

Biotech

  • @XX62source ↗ A forthcoming JEM study describes receptor tethered IL 2 designed to reinforce Treg survival and Foxp3 activity from within the cells.
  • @khalidkarimsource ↗ NUS, Cortical Labs and DayOne are reported to be testing biological computing units built from lab grown human neurons.

Tech

  • @ScanmyphotosCsource ↗ One small business reports that every new online order on Saturday came from customers referred by AI chat systems.
  • @SVTrivosource ↗ A veteran semiconductor engineer says the sector is seeing unprecedented public interest while retaining strong long term growth potential.

Japanese Politics

  • @kohakuototosource ↗ 福岡県議会の疑惑を題材に、地方議員と後援組織が国会議員の選挙生命を握る自民党地方組織の構造を論じている。
  • @GaihekIPikarinsource ↗ れいわ、日本保守党、参政党を比較し、国会議員数より地方議員と地域組織の厚みが長期的な党勢を左右すると分析している。
IV Sky over Ibaraki
☁️ +29°C
humidity 68% · wind ↗4 km/h
cloudy with a light breeze
V What Rex Can Do Today
  1. Summarize the latest AI drug discovery and biotech items into a short research note.
  2. Prepare the Fr. Conor YouTube handoff retry checklist before the 14:15 calendar item.
  3. Scan for urgent travel or meditation pipeline emails and turn them into a concise action list.
VI Toward the Long Game
  1. Read the latest Rentosertib coverage and map the path from AI target discovery to clinical validation.
  2. Run a small local Qwen experiment on literature extraction from a drug discovery paper.
  3. Spend 30 minutes on a current generative chemistry paper and reproduce one simple RDKit workflow.