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REX·DAILY
Thursday September 3 Anno 2026 · Ibaraki, Osaka
I Daily Wisdom
Robert Greene The Daily Laws September 3 · Attack the Center of Gravity

The first principle is that the ultimate substance of enemy strength must be traced back to the fewest possible sources, and ideally to one alone. . . . By constantly seeking out the center of his power, by daring all to win all, will one really defeat the enemy.

—Carl von Clausewitz

It is the nature of power to present a forceful front, to seem menacing and intimidating, strong and decisive. But this outward display is often exaggerated or even downright deceptive, since power does not dare show its weaknesses. And beneath the display is the support on which power rests—its “center of gravity.” The phrase is von Clausewitz’s, who elaborated it as “the hub of all power and movement, on which everything depends.” To attack this center of gravity, to neutralize or destroy it, is the ultimate strategy, for without it the whole structure will collapse. Hitting the enemy’s center of gravity there is the best way to end a conflict definitively and economically. In looking for those centers, it is crucial not to be misled by the intimidating or dazzling exterior, mistaking the outward appearance for what sets it in motion. You will probably have to take several steps, one by one, to uncover this ultimate power source, peeling away layer after layer.

Daily Law: When you look at your rivals, search for the center of gravity that holds the entire structure together. That center can be their wealth, their popularity, a key position, a winning strategy. Hitting them there will inflict disproportionate pain.

The 33 Strategies of War

, Strategy 16: Hit Them Where It Hurts—The Center-of-Gravity Strategy

Steven Pressfield The Daily Pressfield Day 246

“WRITING IS A BAD IDEA” I got this note a few days ago from a writer named Kati Reijnonen. I didn’t know Kati. I had never met her, had never had any contact wi th her. Dear Pressfield and company, I am a Finnish writer, just submitted my third manuscript to the publisher. I have been reading Steve’s blogs and also books. They are very encouraging and uplifting but I have to say I disagree with Steve. I left everything to pursue my dreams [but] the situation is that at the age of sixty, I am broke. I have spent [everything I had.] It’s all gone now. I have no idea what to do next … My Muse has left me. I feel sorry to have written this but what I have written is my truth. “Writing Wednesdays,” stevenpressfield.com, 2/12/20 I wrote back to Kati, asking her if she would let me print her letter for the following Writing Wednesday. I thought it might strike a nerve among the writers and artists who follow the blog. It did.

Leo Tolstoy A Calendar of Wisdom September 3

God cannot be understood by the human intellect, only felt by the human heart.

We only know that he exists, and regardless of whether we want it or not, we know this for sure.

The intellect is like a light that comes through a translucent glass: I see it, and though I do not know where it comes from, I know that it exists.

We can say the same about God.

Believe in God, serve Him, but don’t try to understand His essence.

You will get nothing from your painful efforts except disappointment and fatigue.

Do not even strive to find out whether he exists or not, just serve him as if he does, as if he is present everywhere.

Nothing else is necessary.

—PHILEMON

No one except God comprehends the secret of the great beginning; no one can step outside himself.

—OMAR KHAYYAM

We can understand the existence of God with our intellect only when we understand our complete dependence on him, as if we have the same feeling an infant understands when his mother holds him.

A baby does not know who feeds him, who warms him, who takes care of him, but he understands that there

is

someone who does this, and even he loves the force in whose power he rests.

Do not be alarmed if the notion of God is not clearly expressed to you.

The more clearly it is expressed, the further it is from the truth, from its foundation.

III Signals & Dispatches

AI / ML

  • @claudeaisource ↗ Claude now supports background computer use in Claude Cowork and Claude Code, clicking, typing, and opening apps while you work.
  • @OfficialLoganKsource ↗ Google introduced Gemini 3.8 Flash, highlighting another jump in agentic and coding capabilities.

Drug Discovery

  • @TrendyVestsource ↗ A new analysis argues that impressive Phase 1 numbers for AI discovered drugs still face a much harder Phase 2 and approval wall.
  • @APACLongevitysource ↗ Insilico Medicine’s AI discovered rentosertib has entered Phase 3 development for idiopathic pulmonary fibrosis, according to the summit announcement.

Biotech

  • @GENbiosource ↗ A first clinical trial of CAR T therapy for treatment resistant rheumatoid arthritis reportedly improved all six patients, with three reaching sustained medication free remission.
  • @OwenGregoriansource ↗ Stanford researchers engineered natural killer cells that slowed multiple solid tumors in mice and are preparing a Phase 1 combination trial.

Tech

  • @AlphaSenseIncsource ↗ Broadcom CEO Hock Tan expects $350 billion in AI semiconductor shipments across fiscal 2027 and 2028, while claiming its XPUs cost less than half as much as alternatives.
  • @dhhsource ↗ Omarchy is moving toward a streamlined installer for Apple M machines, letting users try it first and choose the disk space it gets.

Japanese Politics

  • @HirokoKadosource ↗ Hiroko Kado is urging stronger river, sewer, detention basin, and evacuation investments as Japan faces heavier short duration rainfall.
  • @satoshi_hamadasource ↗ Satoshi Hamada revisited the 1923 earthquake’s false anti Korean reports and linked them to his parliamentary questioning of the government’s recognition of the resulting violence.
IV Sky over Ibaraki
🌦️ +26°C
humidity 82% · wind ↙4km/h
showers possible
V What Rex Can Do Today
  1. Draft a one page note connecting today’s AI drug discovery signals to StemRIM’s peptide and regenerative medicine strategy.
  2. Review the Fr. Conor meditation schedule and flag any release or metadata gaps.
  3. Prepare a concise follow up brief from the strongest X signals for future internal use.
VI Toward the Long Game
  1. Read one recent paper on the clinical translation bottleneck for AI generated drug candidates, then write three implications for target product profiles.
  2. Spend 30 minutes reproducing a small molecular property prediction baseline and compare it with a foundation model.
  3. Contact one researcher or founder in AI native biotech with a specific question about validation.