Tuesday, September 8

I Daily Wisdom

Robert Greene The Daily Laws September 8 · Exploit the Chaos

Chaos—where brilliant dreams are born.

—The I Ching

Think of your mind as an army. Armies must adapt to the complexity and chaos of modern war by becoming more fluid and maneuverable. The ultimate extension of this evolution is guerrilla warfare, which exploits chaos by making disorder and unpredictability a strategy. The guerrilla army never stops to defend a particular place or town; it wins by always moving, staying one step ahead. By following no set pattern, it gives the enemy no target. The guerrilla army never repeats the same tactic. It responds to the situation, the moment, the terrain where it happens to find itself. There is no front, no concrete line of communication or supply, no slow-moving wagon. The guerrilla army is pure mobility. That is the model for your new way of thinking. Apply no tactic rigidly; do not let your mind settle into static positions, defending any particular place or idea, repeating the same lifeless maneuvers. Staying in constant motion you show your enemies no target to aim at. You exploit the chaos of the world instead of succumbing to it.

Daily Law: Attack problems from new angles, adapting to the landscape and to what you’re given.

The 33 Strategies of War

, Strategy 2: Do Not Fight the Last War—The Guerrilla-War-of-the-Mind Strategy

Steven Pressfield The Daily Pressfield Day 251

THE WRITER’S HEART OF DARKNESS Here’s part of what I wrote to Kati: Yours is every writer or artist’s nightmare. It’s in everybody’s head all the time, whether they address it or try not to think about it. My own answer is that of course the dream of making a living as a writer or an artist or entrepreneur is a tremendous long shot. That said, the idea of following one’s Muse is a lifelong enterprise, one that we are faithful to for its own sake and not for worldly rewards. That to me is not only an honorable and noble way to live but the ONLY way for many of us. Are you familiar with Elizabeth Gilbert, the author of Eat, Pray, Love and other books? Ms. Gilbert says that at the start of her career she made a deal with her writing. She said, “I will never ask you to support me. I will always support you.” “Writing Wednesdays,” stevenpressfield.com, 2/27/20 Kati did a great favor to all of us by letting out her cri de coeur and posting it in public. I thank her and every soul who responded. The struggle is the same for all of us.

Leo Tolstoy A Calendar of Wisdom September 8

At that time Jesus answered and said, I thank thee, O Father, Lord of heaven and earth, because thou hast hid these things from the wise and prudent, and hast revealed them unto babes.

Even so, Father: for so it seemed good in thy sight.

—MATTHEW 11:25-26

The world would be a terrible place without newborn children, who bring with them innocence, and the hope of man’s further perfection.

—JOHN RUSKIN

Childhood is blessed by heaven because it brings a piece of paradise into the cruelties of life.

All these thousands of everyday births are fresh additions of innocence and purity, which fight against the end of mankind, and against our spoiled nature, and against our complete immersion into sin.

—HENRI AMIEL

O Lord our Lord, how excellent is thy name in all the earth!

who hast set thy glory above the heavens.

Out of the mouth of babes and sucklings hast thou ordained strength because of thine enemies, that thou mightest still the enemy and the avenger.

—PSALMS 8:1-2

What time could be better than childhood, and what virtues could be better than innocent joyfulness, and the need for love?

They are the purest manifestations of life.

You should respect every person, but you should respect a child above all, and not destroy the innocent purity of his soul.

III Signals & Dispatches

AI / ML

@GergelyOrosz source ↗ OpenAI reportedly resisted heavier internal tooling investment proposed by ex Meta hires, betting that an AGI first strategy would make such teams unnecessary.
@levie source ↗ Levie argues AI is expanding output in markets without finite demand, so automation can increase what companies do instead of simply cutting jobs.

Drug Discovery

@SiliconSnark source ↗ A new discussion of InSilico Medicine’s rentosertib reports six aging clocks showing younger biomarker patterns, a striking but still early translational claim.
@thebillyboone source ↗ AI is making the search phase of physical science cheaper, pushing capital toward drug discovery, longevity, materials, batteries, and lab automation.

Biotech

@OncLive source ↗ An MSKCC perspective warns that high risk myeloma biology may outrun CAR T benefit when treatment is delayed, sharpening the case for earlier patient selection.
@ScienceCrisp source ↗ A new report describes CRISPR Cas9 excision of HTLV 1 provirus in patient cells, with proviral load reduced by more than 50%.

Tech

@davelee source ↗ The absence of a steering wheel and pedals makes Tesla’s Cybercab feel like a genuinely different passenger space, not just another robotaxi.
@kunchenguid source ↗ As AI writes more source code, end to end tests matter more because they guard the behavior users actually experience.

Japanese Politics

@TOKYO_Shuto634 source ↗ NHK reports that LDP leadership and cabinet reshuffles are being coordinated for next week ahead of Diet deliberations.
@kokkai_clip source ↗ Nine new Diet records were released, including Cabinet Committee proceedings on science and innovation law and a flag desecration bill.

IV Sky over Ibaraki

🌦️ +24°C

humidity 88% · wind ↙9km/h

showers possible this morning

V What Rex Can Do Today

Review the Fr. Conor meditation schedule and flag any release or proofreading gaps.
Check the Rex automation projects for stale failures and tidy one small issue.
Prepare a concise note on AI drug discovery infrastructure, focusing on governance and wet lab validation.

VI Toward the Long Game

Read one recent paper on generative molecular design and reproduce a small benchmark in Python.
Study how earlier patient selection changes the value proposition of cell therapy in high risk disease.
Contact one AI drug discovery or translational biology researcher with a specific question about clinical data governance.