Wednesday, September 9

I Daily Wisdom

Robert Greene The Daily Laws September 9 · See the Larger Dangers That Loom in the Future

Experience shows that, if one foresees from far away the designs to be undertaken, one can act with speed when the moment comes to execute them.

—Cardinal Richelieu

According to the cosmology of the ancient Greeks, the gods were thought to have complete vision into the future. They saw everything to come, right down to the intricate details. Men, on the other hand, were seen as victims of fate, trapped in the moment and their emotions, unable to see beyond immediate dangers. Those heroes, such as Odysseus, who were able to look beyond the present and plan several steps ahead, seemed to defy fate, to approximate the gods in their ability to determine the future. The comparison is still valid—those among us who think further ahead and patiently bring their plans to fruition seem to have a godlike power. Because most people are too imprisoned in the moment to plan with this kind of foresight, the ability to ignore immediate dangers and pleasures translates into power.

Daily Law: Overcome the natural human tendency to react to things as they happen, and instead train yourself to step back, imagine the larger things taking shape beyond your immediate vision.

The 48 Laws of Power

, Law 29: Plan All the Way to the End

Steven Pressfield The Daily Pressfield Day 252

THE FRUITS OF OUR LABOR Krishna declared to Arjuna: “You have a right to your labor, but not to the fruits of your labor.” It took me a long time to understand this truth…and even longer to accept it. Writing Seminar, Nashville 2019 Can we work, you and I, for the work alone and not for whatever recognition or reward we hope to gain f rom it?

Leo Tolstoy A Calendar of Wisdom September 9

The knowledge we now accept as science interferes with more than it supports the goodness of human life.

Astronomy, mechanics, physics, chemistry, and all other sciences together and differently, all study the particular sides of life, but they do not come to any conclusion about the spiritual life of mankind.

Science fulfills its purpose, not when it explains the reasons for the dark spots on the sun, but when it understands and explains the laws of our own life, and the consequences of violating these laws.

—JOHN RUSKIN

No matter how great our knowledge may be, it cannot help us fulfill our life’s major purpose—our moral perfection.

II The Day Ahead

Tomorrow · 18:30 サークル（木） 2026年間予定

III Signals & Dispatches

AI / ML

@OpenAI source ↗ OpenAI says it is sharing an AI generated solution to the Navier Stokes Millennium Prize problem, with formal verification still central to the claim.
@JoshARosen source ↗ A new thread argues that LLM as judge evaluations should live inside the agent runtime, a practical direction for more reliable agents.

Drug Discovery

@ZainKhalpey source ↗ A small 42 person trial reported that AI designed rentosertib shifted six proteomic aging clocks, an intriguing but early signal alongside its fibrosis program.
@NTI_WMD source ↗ AI acceleration in drug discovery and protein design is also sharpening biosecurity concerns, making safeguards part of the research agenda.

Biotech

@GoogleDeepMind source ↗ AlphaGenome Atlas maps predicted effects of all 9 billion possible single letter DNA variants in a searchable resource for researchers.
@ScienceCrisp source ↗ A new report warns that standard RT qPCR can overestimate RNA target CRISPR knockdown because guide RNA interference creates a measurement artifact.

Tech

@VaseGod source ↗ Mistral reportedly raised 3 billion euros at a 21 billion euro valuation with Samsung and ASML among the lead investors, a strong industrial vote for open weight AI.
@ctatedev source ↗ A 27.5 kilobyte model running locally in the browser uses WebGPU to infer syntax highlighting without being told the language.

Japanese Politics

@kokkai_clip source ↗ New House of Councillors minutes have been published for June 24 and June 26, including debate on revisions to the Ministry of Defense Establishment Act.
@servant1480 source ↗ A Mainichi Shimbun piece examines how a cabinet reshuffle could affect 49 sixth term lawmakers still waiting for ministerial appointments.

IV Sky over Ibaraki

🌦️ +25°C

humidity 93% · wind ↙9km/h

showers possible · humid morning

V What Rex Can Do Today

Audit the Fr. Conor meditation schedule against its Dropbox master and flag any date or title discrepancies.
Prepare a concise evidence table on AI designed drug discovery, including rentosertib, original papers, clinical stage, and open limitations.
Draft a one page internal concept for running peptide discovery workflows locally on the DGX Spark while keeping proprietary data on premises.

VI Toward the Long Game

Read the Nature Biotechnology report on rentosertib and extract the target discovery loop, molecular design method, endpoints, and caveats.
Build a small RDKit baseline that predicts one molecular property, then compare a classical model with a graph neural network.
Study agent evaluation design and implement a tiny test harness with fixed tasks, graders, and regression tracking.