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REX·DAILY
Friday September 25 Anno 2026 · Ibaraki, Osaka
I Daily Wisdom
Robert Greene The Daily Laws September 25 · Stay Away from the Corners

In almost all board games—chess, go (wei chi), backgammon, et cetera—the corners spell defeat and death. These corners also exist on higher, more abstract planes. As you are right now, in your profession or relationships or battles that you face, you could be backing yourself into a corner. And the thing is, you are rarely aware of it as it happens, because often it is when you are excited and emotional, feeling engaged and moving in some direction, or that you have solved a problem, that you inadvertently trap yourself. There are always ways to get yourself out, in a tactical sense, but the wisest course is to become a strategist in the Sun Tzu sense of the term. What matters in the Sun Tzu universe are not positions of strength and power, but situations in which you have options, full of potential force. On a career level, for instance, I always advise people to look ahead and be open to changes in direction. That job that seems so good now can easily turn into a nightmare if you do not see the possible corners it can land you in. I know, because working in Hollywood, seduced by the pay, I backed myself into such a corner. I only got out by thinking far ahead and plotting a much different direction in my life. Instead of aiming at becoming a screenwriter, a trapped position if ever there is one, I aimed at writing books on subjects that excited me and presented endless possibilities for going in this or that direction, even returning to screenwriting, if I wanted to, but on my terms.

Daily Law: Strategists think differently than the way many are used to, in which so much revolves around moving toward a goal. That is linear thinking. What you want is to always aim to increase your options for power and mobility.

“Corners,” powerseductionandwar.com

Steven Pressfield The Daily Pressfield Day 268

THE HERO ACTS ON AN INTENTION Our hero acquires her intention in the Inciting Incident of Act One. In Act Two she pursues that intention. Dorothy seeks the Wizard of Oz. Esty Shapiro (Shira Haas) in Unorthodox flees her Chasidic community (and her husband) in Brooklyn and flies to Berlin, Germany. Her intention is to live as a free woman. Mark Watney (Matt Damon), left behind on Mars, intends to survive until he can be rescued. Unpublished Black Irish JAB, “Act Two Horrors” The hero’s intention is the reason he or she “crossed the threshold.” To solve the crime, to find love, to expunge or expiate some act of wrongdoing. But in Act Two, the hero comes face to face with a force he or she had only begun to deal with in Act One…the Villain.

Leo Tolstoy A Calendar of Wisdom September 25

Work is not a virtue, but it is the necessary condition of a virtuous life.

Hurried work done in irritation attracts the unfavorable attention of others.

Real work is always quiet, constant, and inconspicuous.

It is not enough to be a hardworking person.

Think: what do you work at?

—HENRY DAVID THOREAU

For every idle person, there is another person who works too much.

For every person who eats to excess, there is another person somewhere who is hungry.

Much of the activity of idle people who pretend that they are busy with work is merely entertaining; it just adds a burden to other people.

This can be said of all luxuriant entertainments.

II The Day Ahead
  • Tomorrow · 09:00 毎月の黙想会 2026年間予定
  • Tomorrow · 15:30 Miu & Pierre Wedding ewijaya@gmail.com
III Signals & Dispatches

AI / ML

  • @paulgsource ↗ Paul Graham compares today’s debate over whether LLMs ‘think’ to heliocentrism being used for calculation before it was fully accepted.
  • @goodsidesource ↗ Claude Opus 5.5 wrote and animated a Zen-koan-inspired scene, showing code-first models moving beyond static text.

Drug Discovery

  • @_farrahmaysource ↗ Envisagenics and Boehringer are using AI to screen more than 14 million RNA-splicing events for cancer targets, with wet-lab validation still the bottleneck.
  • @EntrepreneursAIsource ↗ Anthropic has opened beta access to more capable Claude models for verified life-science teams working on drug discovery, development, and manufacturing.

Biotech

  • @BioWorldsource ↗ Earendil’s AI platform reportedly landed a $1.5 billion collaboration with Genentech in oncology.
  • @piske_ccsource ↗ A summary of Anthropic’s biology work says roughly 950 Claude agents searched more than 200,000 candidates and narrowed them to a CRISPR-like enzyme system now being validated.

Tech

  • @jasonfriedsource ↗ Jason Fried says agentic tools have restored his ability to write and design software himself after years of directing other people.
  • @dhhsource ↗ DHH argues Apple’s central problem is software and product direction, not hardware, despite its latest leadership move.

Japanese Politics

  • @cobtasource ↗ Fujii Seira criticizes Prime Minister Takaichi for posting about gluten-free food after returning from the US while Chiba flooding remained unaddressed.
  • @Kanesan1107source ↗ A Japan Conservative Party policy post argues Kitakyushu should prepare for future security and integration pressures, citing local demographic changes.
IV Sky over Ibaraki
☁️ +21°C
humidity 72% · wind ↓9 km/h
cloudy with light wind
V What Rex Can Do Today
  1. Prepare a one-page evidence note on Anthropic’s reported CRISPR-like enzyme discovery, separating confirmed results from hype.
  2. Check the recursive-mol Phase 2 sweep and surface any new best score, stalled jobs, or budget changes.
  3. Review the medical-records app for stale medication entries before Boss relies on its current status.
VI Toward the Long Game
  1. Read Anthropic’s primary report on the reported enzyme discovery and extract the experimental claims, limitations, and next experiments.
  2. Build a small molecular-design benchmark comparing a conventional virtual-screening baseline with an AI-assisted workflow.
  3. Reach out to one AI-for-drug-discovery researcher or register for one relevant seminar this week.